Meniscense’s patent pending volume measurement technology uses optical interferometry to determine the liquid fill level of microplate wells. Optical interferometry is a well-established method in the precision metrology of solid surfaces such as optical and microelectromechanical components. Applied to liquids, interferometric surface profiling offers a high-resolution and non-contact means for volume measurement, avoids the potential for sample contamination, and does not require adding dyes. The sample remains unaffected, so real time monitoring becomes possible.
We have recently published a peer-reviewed paper[1] on our technology and demonstrated a volume resolution of < 0.02 µl and a volume inaccuracy of < 2% in 96-well plates.
Our technology delivers better data, because results reflect the physicochemical properties of the actual sample, rather than relying on calibrated dye solutions as dummy reagents. It reduces costs and test times, because monitoring does not consume precious sample, and because no custom consumables or lengthy calibrations are required. Our technology senses light from a probe beam reflected at the liquid surface, and it can be applied to essentially any liquid, including turbid samples and samples containing beads or cells. Our instrument has a form factor that permits placing it on the deck of a typical liquid handling robot, where the plate can be accessed for pipetting or plate transfer operations. This allows for seamless, near real-time integration into liquid handling workflows. Users save time because they do not need to run a dedicated liquid handling program to perform a volume measurement, reconfigure the robot, or remove the plate from the robot, as competing methods require. There is currently no other solution on the market that offers the same combination of benefits.
The development of Meniscense’s technology is at a proof-of-concept stage. We are currently working on our first product and exploring application areas as well as partnering opportunities.
[1]Contact us for a copy of our whitepaper.
We have recently published a peer-reviewed paper[1] on our technology and demonstrated a volume resolution of < 0.02 µl and a volume inaccuracy of < 2% in 96-well plates.
Our technology delivers better data, because results reflect the physicochemical properties of the actual sample, rather than relying on calibrated dye solutions as dummy reagents. It reduces costs and test times, because monitoring does not consume precious sample, and because no custom consumables or lengthy calibrations are required. Our technology senses light from a probe beam reflected at the liquid surface, and it can be applied to essentially any liquid, including turbid samples and samples containing beads or cells. Our instrument has a form factor that permits placing it on the deck of a typical liquid handling robot, where the plate can be accessed for pipetting or plate transfer operations. This allows for seamless, near real-time integration into liquid handling workflows. Users save time because they do not need to run a dedicated liquid handling program to perform a volume measurement, reconfigure the robot, or remove the plate from the robot, as competing methods require. There is currently no other solution on the market that offers the same combination of benefits.
The development of Meniscense’s technology is at a proof-of-concept stage. We are currently working on our first product and exploring application areas as well as partnering opportunities.
[1]Contact us for a copy of our whitepaper.